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The decrease in the level of intestinal FXR is correlated with decrease in the secretion of an enterokine that regulate synthesis of hepatic bile acid fibroblast growth factor 15/19 (FGF15/19), which in turn can reduce liver steatosis (134)

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a) the hair follicle status is determined by a method according to the invention for extracorporeal analysis of hair follicle cells or by a method according to the invention for the extracorporeal determination of the ATP synthesis rate in hair follicle cells, b) applying an active substance once or several times to the hairy skin in order to maintain or promote homeostasis of the hair follicle or to treat pathological conditions of the hair follicle, c) again determines the hair follicle status by a method according to the invention for extracorporeal analysis of hair follicle cells or by a method according to the invention for extracorporeal determination of the ATP synthesis rate in hair follicle cells, and d) the effectiveness of the active substance is determined by comparing the results of a) and c)

10.1139/y75-011 Can J Physiol Pharmacol

Salsbury RL, Merricks DL