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These limitations underscore the need for delivery innovations such as nanoparticle encapsulation, liposomal formulations, and prodrug designs to enhance bioavailability, protect compounds from first-pass metabolism, and improve tissue-specific targeting

The body will store some B12, but not in excessive amounts, and since it can easily dissolve in water, excess B12 gets excreted in urine

Although the therapeutic advantages of EVs are evident, there are still shortcomings in practical application, such as low therapeutic efficiency and rapid degradation rates (Sterzenbach et al., 2017

Highlight the importance of increased fiber intake for improved blood glucose levels and other health benefits

Clin Gastroenterol Hepatol 2025;23:797-807.e5

Progerin is a shortened lamin protein related to the Hutchitson-Gilford progeria syndrome (HGPS) which accumulates by cumulative shortening of telomere throughout fibroblast cells senescence [132]