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Some drugs affected by the CYP1A2 isoenzyme system include psychiatric medications (eg, clozapine, olanzapine, imipramine, diazepam, ramelteon), antihypertensive drugs (eg, propranolol, verapamil), opioid analgesics (eg, propoxyphene), anticoagulants (warfarin), and drugs used to treat asthma and other respiratory problems (eg, theophylline)

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However, our results suggest that this benefit is outweighed by higher risks of stroke, heart disease, heart failure and death from any cause

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