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Shi Y, Lai X, Ye L, Chen K, Cao Z, Gong W, et al

This indicates that (i) Palbociclib treatment readily elicits a resistant phenotype both in vitro and in vivo, (ii) the combination of Palbociclib with Telaglenastat disables Palbociclib-induced resistance mechanisms in vitro and in vivo and (iii) the disabling of resistance mechanisms by this drug combination is heritable through many cell generations