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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Satarug S., Gobe G.C., Vesey D.A

Consistent with an induction of oxidative stress condition, metformin increased mRNA levels of the master redox transcription factor Nrf-2 (nuclear factor erythroid-derived 2-like), as well as transsulfuration enzymes cystathionine beta-synthase and cystathionase and GSH synthesis enzymes -glutamylcysteine synthetase and glutathione synthetase

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and cognitive therapy (eg, changing negative thoughts about sleep to more realistic ones, avoiding blaming negative events on poor sleep, establishing real expectations related to insomnia and the need for sleep)