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In vivo anti-aging effects of naringin, a bioflavonoid: insights from the budding yeast Saccharomyces cerevisiae as a model organism

Consequently, even after oral administration of high doses, plasma and tissue concentrations of the native compound remain substantially below the levels required to elicit significant pharmacological effects within the central nervous system

J Neurosci 18:24752485 Miyakawa H, Woo SK, Dahl SC, Handler JS, Kwon HM (1999) Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity