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In terms of genomic instability, gain-of-function mutations of proto-oncogenes (e.g., KRAS, 10 BRAF, 11 EGFR 12 and ERBB2 13 ), loss-of-function mutations of tumor suppressor genes (e.g., TP53, 14 PTEN 15 and APC 16 ), and defects in DNA damage repair genes (e.g., BRCA1/2, 17 MSH2 and MLH1 18 ) have been reported to drive tumorigenesis in a number of cancer types

The groups that received the riboflavin-fortified salt had lower rates of esophageal cancer.[ref] Inflammatory Bowel Disease (IBD): In patients with Crohns disease, riboflavin (100mg/day) decreased inflammatory markers significantly in three weeks.[ref] Related article: IBD and Genetic Connections Inflammation: A randomized, placebo-controlled trial of supplemental riboflavin found that it reduced inflammation based on a lower CRP level.[ref] Related article : Inflammation and chronic disease Gut microbiome interactions with riboflavin: Certain gut microbes can produce riboflavin, part of which is then absorbed into the body