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J Pharmacol Exp Ther 311, 677682

doi: 10.3390/ijerph192013300 68 YangQ.ZhangL.ChangF.YangH.ChenB.LiuZ

Li Yajuan

10.1074/jbc.M414178200 J

The best human sleep studies on DSIP date from the 1980s and 1990s, with sample sizes typically under 20 subjects and no modern RCT replication, placing overall evidence confidence at Low to Very Low

There are likely to be side effects related to hormonal shifts such as fluctuations in libido, energy, or sleep, mood swings, and irritability as the bodys endocrine system adapts