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Beyond nausea, the gastrointestinal side effect cluster includes diarrhea, vomiting, constipation, and decreased appetite, which is technically a desired effect but can become problematic at extreme levels

Its effects contribute to improved tissue adaptability and long-term structural integrity

Protects against bleomycin-induced pulmonary fibrosis in mice via anti-inflammatory and anti-fibrotic mechanisms 2,3

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling

Both studies met the primary endpoint of treatment success as determined by a score of clear or almost clear on the validated Investigator Global Assessment-Atopic Dermatitis scale, alongside a two-grade improvement at four weeks

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