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It has recently been demonstrated that in many cancer cell lines, including leukemia (L1210FR), ovarian (Ov2008, ID8), colon (Colo-26), mastocytoma (P815), lung (M109), renal (RENCA, RD0995), and breast (4T1, JC, MMT06056) cancer cell lines, biotin receptors are overexpressed more than folate and/or vitamin B-12 receptors (155, 156)

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doi: 10.3389/fcell.2023.1127618 Received 19 December 2022 Accepted 16 February 2023 Published 27 February 2023 Volume 11 - 2023 Edited by Alessandro Luciani, University of Zurich, Switzerland Reviewed by Sean Froese, University Childrens Hospital Zurich, Switzerland Dario Brunetti, University of Milan, Italy Updates Copyright 2023 Li and Hoppe