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In various tumor types, p53 mutations not only result in the loss of its tumor suppressor function but may also confer new oncogenic functions to the mutated p53, a phenomenon termed gain-of-function (GOF) ( The p53 protein plays a crucial role in cell cycle regulation and apoptosis

Acknowledgements We thank and Sujeong Eom, MS (VUNO Inc, Seoul, Republic of Korea) for assistance with protocol development and Jaehyun Shin, MFA (Research Associate, Department of Biomedical Systems Informatics, Yonsei University College of Medicine) for providing support with figures

Fortenberry GZ, Beckman J, Schwartz A, Prado JB, Graham LS, Higgins S, et al

Ince C, Ashruf JF, Avontuur JA, et al