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Interstitial fluid is an ultrafiltrate of plasma: It has nearly the same composition as plasma, excluding plasma proteins and blood cells

Transforming growth factor (TGF)--activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit (PKAC) and X-linked protein kinase (PRKX)

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This may lower Alzheimer's and Parkinson's disease risk