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Key Takeaways Cigarettes dont usually display an expiration date, but they do degrade over time The shelf life ranges from a few weeks (opened) to up to a year (unopened) Poor storage conditions, especially exposure to direct sunlight, accelerate deterioration Expired cigarettes affect smoking experience, including taste and burn rate All tobacco use carries risks, regardless of product freshness Alternative products like electronic cigarettes and their refill liquids also have defined lifespans IQOS is not risk-free and provides nicotine, which is addictive

How to Observe Cigarettes are Hazardous to Your Health Day Avoid cigarette smoking Cigarettes Are Hazardous to Your Health Day is a good day to abstain from cigarette smoking

The Content Expert Panel suggests investigators consider nicotine as derived from any source, including both natural and synthetic, when administering this protocol

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For more information about the Consortium and THS research, please contact Hugo Destaillats ([email protected]), Bo Hang, ([email protected]) and Antoine Snijders ([email protected])