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In the biomarker discovery and validation set, the disease group consisted of a mixture of patients exposed and unexposed to drug treatment including antidepressants for the treatment of MDD

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The development of type 2 diabetes and its complications have been linked to disturbances in the metabolism of amino acids, specifically gluconeogenic amino acids (40)

The APOE-TR model is a mouse knock-in model where exons 24 (comprising the mouse APOE gene) are replaced with human APOE in 129xC57BL/6 mice back-crossed to C57BL/6 mice (Sullivan et al., 1997)

D., & Avants, S

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