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S-Glutathionylation occurs extensively in diseases characterized by oxidative stress, including cardiovascular diseases, cancer, lung diseases, neurodegenerative diseases, and cancer

This triggers the MAPK cascade, such that Ras-GTP activates Raf [also called MAPK kinase kinase (MAPKKK)], which in turn activates MEK1/2 [MAPK kinase (MAPKK)]

pK 1 2.12

Without enough glutathione, these reactive intermediates can sit in the liver and cause oxidative stressan imbalance between free radicals and antioxidants that can lead to cellular damage

(2004) doi:10.1097/00006250-200404000-00045

UV spans 100400 nm and includes UVA (315400 nm), UVB (280315 nm), and UVC (100280 nm)