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A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis

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Subsequently, the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) Working Group approach was used to evaluate the certainty of the evidence for each identified treatment modality on a per outcome basis (Supplementary Information: Appendix B) [16]

For example, in the TRANSFORMER study, patients with mCRPC who had not received prior BAT exhibited a PSA 50 response rate of 25% and median response duration of 3.8 months while on the AR inhibitor enzalutamide, while patients who had progressed on BAT exhibited a PSA 50 response rate of 78% and median duration of response of 10.9 months while on enzalutamide (9)

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