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After the pituitary releases growth hormone in response to sermorelin, the liver converts a significant portion of that GH into IGF-1, which mediates many of GHs downstream effects on fat metabolism, muscle maintenance, and tissue repair

doi: 10.1371/journal.ppat.1011406 176 ChitimusDMet al

The mitogen-activated protein kinase (MAPK) family comprises three major subfamilies with distinct and sometimes opposing functions: extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 MAPK