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The smoking rate among people aged 15 and older fell from 36.2% in 2000 to 21.3% in 2022, a decline of 14.9 percentage points or roughly 40% over the period

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Epidemiologic investigations have revealed that smoke exposure is associated with the imbalance of Tregs in COPD patients or smokers

Since e-cigarettes were first introduced, device type purchases and preferences have changed over time 7,8

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