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It requires activation by the mycobacterial F420 coenzyme system, including Ddn, to exert its antimycobacterial activity

And previously, the Surgeon General found that the nicotine in e-cigarettes can harm the developing lungs of youth and alter adolescent brain development

And in this regard, the results are reassuring: although these products have appeared relatively recently (around 2010), the available data suggest that they have not had negative impacts on the adoption of cigarettes by young people: in the United States, for example, the smoking cessation rate is 3 to 4 times higher between 2010 and today than between the period from 1975 to 2010, suggesting that e-cigarettes have instead accelerated the reduction of youth smoking (Figure 1)

Menthol cigarettes, smoking cessation, atherosclerosis, and pulmonary function: the Coronary Artery Risk Development in Young Adults (CARDIA) Study

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eCigarettes may be safer than traditional cigarettes, but there is no science-backed reason to think this in fact, current studies hint that vaping is at least as unhealthy as smoking