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More recently, base editing approaches have been applied to fine-tune the catalytic efficiency of enzymes such as APX1, resulting in improved ROS detoxification under stress conditions

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Furthermore, achieving precise targeting to specific brain regions remains an additional challenge

Oxidation of low-molecular-weight thiols, like Cys and GSH, results in the formation of disulfides and a 2:1 (thiol:oxidant) stoichiometry indicates the participation of a sulfenic acid intermediate

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Slow COMT is strongly linked with traits of OCD (obsessive-compulsive disorder) , addiction , anxiety , and even certain types of ADHD (especially the inattentive type where the person is spacey until pressure hits, then they hyperfocus)