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We further noted in the CY 2026 OPPS/ASC proposed rule that the two neuroplasty procedure codes that could be used with the Axoguard HA+ Nerve Protector TM (CPT codes 64718 and 64721) have previously been used with both categories C1763 and C1765 and that FDA has previously approved devices described by C1763 and C1765 and billed using CPT codes 64718 or 64721 for neuroplasty and/or transposition of the ulnar nerve at elbow or median nerve at carpal tunnel

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However, accumulating evidence has indicated that mitochondrially-localized STAT3 (mitoSTAT3) also plays an important role in regulating the electron transport chain (ETC), mitochondrial DNA transcription, ATP production, cell death, and ROS homeostasis 34,36,38,39

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The data encompasses both physiological and pathological states, mapping how disrupted farnesylation triggers metabolic dysfunction