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Microneedling, mesotherapy-style injections, tattoo-assisted delivery and post-transplant scalp protocols make it easier to place active compounds closer to the follicle

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Murphy and Morton described a phenomenon called the bystander effect in 1915 (19)

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Further, in such an approach, the penetration enhancer is not required, as is sometimes the case with transdermal, nasal, or mucosal oral routes of administration

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