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Importantly, these findings provide a mechanistic explanation for the limited diagnostic value of circulating zinc measurements and the variable clinical efficacy of nonspecific zinc supplementation, which fail to capture or correct compartment-resolved zinc dysregulation

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Li Y, Calfa G, Inoue T, Amaral MD, Pozzo-Miller L (2010) Activity-dependent release of endogenous BDNF from mossy fibers evokes a TRPC3 current and Ca2+ elevations in CA3 pyramidal neurons