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Various computational structure based design methods have been disclosed in the art

RNA interference siRNAs targeting ATXN3 were purchased from Microsynth: siATXN3 #1 UGGCAGAAGGAGGAGUUACTT (Wang et al, 2012), siATXN3 #2 CAGGGCUAUUCAGCUAAGUAUTT (Sacco et al, 2014), siATXN3 #3 GCACUAAGUCGCCAAGAAATT (Ashkenazi et al, 2017), and siATXN3 #4 GCAGGGCUAUUCAGCUAAGTT (Ashkenazi et al, 2017)

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